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2025, Vol: 7, Issue: 2
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Review Article
Online Published: 30 Dec 2024
 


ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM)

Alkanchi N.a., Salihu S., Sidi J.u.


Abstract
The main risk factors for the development of gestational diabetes mellitus (GDM) are age, lifestyle, and diet. The pathogenesis of GDM is characterized by β-cell dysfunction and insulin resistance (IR). As a result of IR's indirect impact on important metabolic enzymes, diabetic people are also more susceptible to aberrant cholesterol and lipoprotein levels. Recent research, however, raised the possibility that lipid alterations might really be the cause of poor glucose metabolism rather than just a symptom of it. The fluidity and permeability of cell membranes, as well as the translocation of glucose transporters and insulin receptor binding and signaling, are all influenced by free fatty acids (FFAs). Thus, it is hypothesized that FFAs may be crucial in the emergence of IR and GDM. The purpose of the current review was to examine FFAs' roles in the pathogenesis of GDM, as it has yet to be fully elucidated.

Key words: Gestational Diabetes Mellitus (GDM), Oxidative stress, insulin Resistance, Free fatty acids, Insulin signaling.


 
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How to Cite this Article
Pubmed Style

N.a. A, S. S, J.u S. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). JIRLS. 2024; 6(2): 79-85.

Web Style

N.a. A, S. S, J.u S. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). https://www.jirlsonline.com/?mno=235397 [Access: June 27, 2026].

AMA (American Medical Association) Style

N.a. A, S. S, J.u S. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). JIRLS. 2024; 6(2): 79-85.


Vancouver/ICMJE Style

N.a. A, S. S, J.u S. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). JIRLS. (2024), [cited June 27, 2026]; 6(2): 79-85.


Harvard Style

N.a., A., S., . S. & J.u, . S. (2024) ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). JIRLS, 6 (2), 79-85.


Turabian Style

N.a., Alkanchi, Salihu S., and Sidi J.u. 2024. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). Journal of Innovative Research in Life Sciences, 6 (2), 79-85.


Chicago Style

N.a., Alkanchi, Salihu S., and Sidi J.u. "ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM)." Journal of Innovative Research in Life Sciences 6 (2024), 79-85.


MLA (The Modern Language Association) Style

N.a., Alkanchi, Salihu S., and Sidi J.u. "ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM)." Journal of Innovative Research in Life Sciences 6.2 (2024), 79-85. Print.


APA (American Psychological Association) Style

N.a., A., S., . S. & J.u, . S. (2024) ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). Journal of Innovative Research in Life Sciences, 6 (2), 79-85.


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