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Research Article 
JIRLS. 2019; 1(1): 97-105


DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn

Umar A. Aminu and Isah M. Fakai.

Abstract
The non-protein amino acid β-N-methylamino-L-alanine (BMAA) has been associated to the development of a number of neurodegenerative diseases in humans including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, and Parkinson’s disease. A range
of cyanobacteria, diatoms, and dinoflagellates that are found in freshwater, saltwater, and terrestrial ecosystems have all been reported to produce BMAA. Axenic laboratory culture of Synechocystis NPLB 2 strain was analysed by high performance liquid chromatographyelectrospray ionization ion trap mass spectrometry. Derivatized BMAA and its structural isomer 2,4-diaminobutyric acid (2,4-DAB) were detected in Synechocystis NPLB 2 strain of cyanobacteria. The presence of these toxins in waters used for various human needs raises concerns for public health.

Key words: Cyanobacteria, BMAA, DAB, HPLC-ESI-MSn, Synechocystis, Derivatized


 
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Pubmed Style

Umar A. Aminu and Isah M. Fakai. DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn. JIRLS. 2019; 1(1): 97-105.

Web Style

Umar A. Aminu and Isah M. Fakai. DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn. https://www.jirlsonline.com/?mno=108750 [Access: January 07, 2024].

AMA (American Medical Association) Style

Umar A. Aminu and Isah M. Fakai. DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn. JIRLS. 2019; 1(1): 97-105.


Vancouver/ICMJE Style

Umar A. Aminu and Isah M. Fakai. DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn. JIRLS. (2019), [cited January 07, 2024]; 1(1): 97-105.


Harvard Style

Umar A. Aminu and Isah M. Fakai (2019) DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn. JIRLS, 1 (1), 97-105.


Turabian Style

Umar A. Aminu and Isah M. Fakai. 2019. DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn. Journal of Innovative Research in Life Sciences, 1 (1), 97-105.


Chicago Style

Umar A. Aminu and Isah M. Fakai. "DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn." Journal of Innovative Research in Life Sciences 1 (2019), 97-105.


MLA (The Modern Language Association) Style

Umar A. Aminu and Isah M. Fakai. "DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn." Journal of Innovative Research in Life Sciences 1.1 (2019), 97-105. Print.


APA (American Psychological Association) Style

Umar A. Aminu and Isah M. Fakai (2019) DETECTION OF NEUROTOXINS BMAA AND DAB INCULTURED CYANOBACTERIAL ISOLATE SYNECHOCYSTIS NPLB 2 USING LC/ESI-MSn. Journal of Innovative Research in Life Sciences, 1 (1), 97-105.


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